MEDICAL DEVICE UNDER DEVELOPMENT, NOT AVAILABLE FOR CLINICAL USE
A re-engineered intracardiac flow system, designed by physiology.
VORTICA is the first mechanical mitral surgical prosthesis specifically designed for the mitral position.
Conventional mitral valve replacements abolish the physiological left ventricular Vortex, leading to disturbed intraventricular flow and impaired ventricular efficiency.
Unlike other mitral prostheses, which are typically based on aortic designs, Vortica is conceived in alignment with the D-shaped anatomy and functional asymmetry of the native mitral valve apparatus and function. The asymmetrical leaflets are designed to restore physiological vortex dynamics within the heart, re-establishing natural flow dynamics and energy-efficient ejection, and promoting safer, more natural circulation that reduces stagnation, turbulence, and the risk of clot formation.
Mythralica’s valve innovation is supported by a high-fidelity simulation ecosystem that models cardiac physiology to accelerate discovery and reduce innovation risk. Advanced computational fluid dynamics, in vitro hydrodynamic testing, high-fidelity Doppler echocardiography, and tomographic particle image velocimetry are used to capture the full complexity of valvular and intraventricular flow, enabling precise evaluation of the VORTICA physiologic prosthesis with unmatched precision.
This integrated platform enables rapid refinement of design concepts, performance testing across diverse anatomies, and identification of optimal geometries prior to fabrication. Furthermore, it supports rigorous benchmarking against native mitral valve apparatus, bileaflet mechanical valves, and tri‑leaflet bioprostheses, ensuring each iteration is based on robust, quantitative, comparative evidence.
Mythralica is developing an AI platform to advance precision medicine in mitral valve therapy. By integrating patient-specific anatomy, clinical data, and advanced computational and experimental measurements of valvular and intraventricular flow, the system predicts individual cardiac responses to the VORTICA physiologic prosthesis. This AI platform forecasts improvements in cardiac function, long-term capacity, and ventricular remodeling following surgery.
Designed for patients with severe mitral valve disease, including primary and secondary regurgitation and rheumatic pathology, the platform evaluates the expected clinical benefit of a physiologic prosthesis prior to intervention. It integrates detailed fluid dynamics and hemodynamic signatures to anticipate changes in symptoms, functional status, and overall cardiac performance. This framework serves as a decision-support tool to guide patient selection, optimize surgical planning, and ensure that each VORTICA implantation is informed by personalized, physiology-driven insights.
For decades, two prosthetic paradigms, mechanical and biological, have co-existed. However, neither has been specifically designed for the mitral position or to restore physiological hemodynamic flow.
01
The premise
The VORTICA design is based on contemporary scientific principles rather than misconceptions underpin current-generation surgical mitral prostheses.
02
The Misconception
Existing prostheses, derived from aortic designs, disregard the valve’s native asymmetry and its role in left-ventricular vortex dynamics.
03
The Breakthrough
Developed through advanced computational modelling and flow analysis, VORTICA restores physiological vortex formation that conventional round and symmetric valves cannot reproduce.